5/7/2023 0 Comments Cephalosporin cross reactivity![]() For the comparison group, the “index” penicillin prescription was the first prescribed penicillin.Īllergic-like events are narrowly defined.ĪLE after both penicillin and second antibiotic Comparison subjects never had an allergic-like event within 30 days after any penicillin prescription. The first penicillin prescription followed by an allergic-like event was called the “index” penicillin prescription. The study group consisted of patients who had an allergic-like event within 30 days after a penicillin prescription. Two subgroups were compared to calculate the risk of an allergic-like event after a cephalosporin. This cohort was used for the primary analyses. The 60-day interval between the first penicillin and the subsequent cephalosporin prescription ensured that an event after the cephalosporin was not a late event associated with the earlier penicillin. Within that population, we identified patients who also received a cephalosporin prescription at least 60 days after a penicillin prescription. We identified all patients in the GPRD UTS database from 1987 to September 2001 who received a prescription for penicillin ( Figure 1). Methods Data Source: General Practice Research Database To better understand etiology, we compared our results with analyses replacing cephalosporin with sulfonamide antibiotics because there is no known structural or immunologic cross-reactivity between penicillin and sulfonamide antibiotics. To study the question of allergic cross-reactivity between penicillins and cephalosporins, we conducted a retrospective cohort study using the United Kingdom General Practice Research Database (GPRD), a database of electronic primary care medical records and prescriptions. ![]() Furthermore, avoidance of an antibiotic because of an allergy history may result in the selection of a less effective or more toxic antibiotic. With the increase in bacterial antimicrobial resistance, particularly multidrug resistance, therapeutic options are increasingly limited. A major component of this research is understanding the risk of cephalosporin hypersensitivity in patients with penicillin allergy. ![]()
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